Writing an Introduction

Host Gene Induction and Transcriptional Reprogramming in Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV-8)-Infected Endothelial, Fibroblast, and B Cells: Insights into Modulation Events Early during Infection

For Move 1, the author introduced the background knowledge about HHV-8, the seriousness of several diseases it causes, the mechanisms of the host responding to the viral infection, and also implied the importance to control the infection. The phrases used to drive this part are “Kaposi’s Sarcoma is …”, “In vitro, HHV-8 has been shown to…”, “The binding of herpes simplex virus type-1 to cell surfaces induces…”, and so on. For Move 2, the phrase author stated “The identification of such cellular signatures might eventually lead to the development of novel strategies to control HHV-8 infection” shows the importance to identify the cellular signatures in the infected patients. Besides, as the Move 3, he briefly described about his research’s methodology, which is to analyze the cellular transcriptional responses in three different target cells in vitro at 2 and 4 h after HHV-8 infection. The phrase he used to introduce is “we undertook this study to…”. The words used are “undertook” and “analyze”.

From:
Naranatt P.P. et al. Host Gene Induction and Transcriptional Reprogramming in Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV-8)-Infected Endothelial, Fibroblast, and B Cells: Insights into Modulation Events Early during Infection. Cancer Res., 64: 72-84, 2004.

Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation

This introduction provided all “Moves”. For “Move1”, the author explained about the mechanisms of specific enzyme that can damage tissue in mice. He gave background about oxidants, and finally came up with the knowledge about vitamin C as an anti-oxidant. Then, he brought the readers to the move 2 by stated that “Despite intense interest in the proposed antioxidant role of ascorbate and other vitamins, however, there is remarkably little evidence that these compounds directly scavenge reactive intermediates in vivo.”. This allows the readers to know the “gap” in this field and the importance to perform this research. Interesting phrases in this move are “Despite intense interest in…, however,…” and “There is remarkably little evidence that…”. Finally, he added the move 3, “To determine whether ascorbate functions as an antioxidant during inflammation, we studied…”, which indicated the approach of this research. The interesting phrase in this move is “To determine…, we studied…”.

From:

Joseph, P.H., Abderrazzaq, B., et al. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Rad. Biol.& Med., 40: 1494-1501, 2006.

Vitamin D, Aging, and the 2005 Dietary Guidelines for Americans

This introduction is driven in different way from the two formers. The author started with a little background and seriousness of vitamin D deficiency to interest readers. He also indicated that the today guidelines for taking vitamin D are not up-to-date. Then, he went to move 2 by stating the importance of vitamin D recommendation. The interesting phrase in this move is “Therefore, it is prudent to…”. After that, he brought his readers to the next move. For move 3, he stated the purpose of his article. The interesting phrase is “The purpose of this article is to review…”. Finally, he came back to the move 1 again to give more background about vitamin D and bring to the next part of his article.

From:

Mary, A.J., Michael, G.K. Nutrition grand rounds: Vitamin D, aging, and the 2005 dietary guidelines for Americans. Nutrition Reviews, 64(9):410-421, 2006.